工作单位：中国海洋大学
通讯地址：青岛市鱼山路5号，海大食品学院
电子邮箱：xzhmao@ouc.edu.cn
研究领域：
主要从事食品生物技术、水产品生物加工和海洋食品生化工程研究，主要工作包括：
（1）食品酶学与生物催化：食品用酶的快速发掘和高效表达，催化机制解析和理性分子改造，生化反应过程优化与调控，以及酶与生物催化转化技术在食品加工过程的应用研究。
（2）水产品生物加工与海洋生物资源绿色高效利用：针对海洋生物资源及其加工副产物，利用生物催化、生物转化和生物发酵等生化工程技术，进行生物加工和绿色全利用，开发新型海洋食品、营养功能食品、保健食品和特医食品等高附加值产品。
（3）海洋功效物质的合成生物学与系统代谢工程：针对食品功效物质的生物合成，通过代谢工程与合成生物学相关技术开展代谢途径的设计、重构与调控研究，并结合生化工程模型化控制理论开展发酵过程优化、调控和放大研究。
主持项目：
近五年主持国家级课题4项，省部级及其他课题10余项。代表性项目如下：
(1)国家自然科学基金：α-新琼二糖水解酶生成奇数琼寡糖的催化机制和产物构效关系研究（项目负责人）
(2)国家自然科学基金：新型β-琼胶酶分子改造及其对琼胶寡糖聚合度的影响机制研究（项目负责人）
(3)国家现代农业产业技术体系项目：虾蟹副产物综合利用（项目负责人）
(4)山东省重点研发计划：生物发酵与催化转化耦合法提取甲壳素、虾青素等海洋活性物质的产业化关键技术（项目负责人）
(5)青岛市应用基础研究计划：特定酰基DHA-磷脂的生物催化机制和工具酶的理性设计研究（项目负责人）
成果及获奖情况等：
以第一作者或通讯作者发表SCI论文60余篇，以第一发明人授权发明专利20余项。代表性学术论文如下：
1. Jing Li, Wen-Can Huang, Li Gao, Jianan Sun, Zhen Liu, Xiangzhao Mao*.Efficient enzymatic hydrolysis of ionic liquid pretreated chitin and its dissolution mechanism. Carbohydrate Polymers, 2019, 211, 329-335.
2. Haiyang Zhang, Wenqin Chu, Jianan Sun, Zhen Liu, Wen-Can Huang, Changhu Xue, and Xiangzhao Mao*. Combining cell surface display and DNA shuffling technology for directed evolution of Streptomyces phospholipase D and synthesis of phosphatidylserine. Journal of Agricultural and Food Chemistry, 2019, 67, 13119-13126
3. Pujuan Zhang#, Jinru Zhang#, Lujia Zhang, Jianan Sun, Yuan Li, Lian Wu, Jiahai Zhou, Changhu Xue, Xiangzhao Mao*.Structure-based design of agarase AgWH50C from Agarivorans gilvus WH0801 to enhance thermostability.Applied Microbiology and Biotechnology, 2019, 103, 1289-1298.
4. Li Gao, Jianan Sun, Francesco Secundo, Xin Gao, Changhu Xue, Xiangzhao Mao*. Cloning, characterization and substrate degradation mode of a novel chitinase from Streptomyces albolongus ATCC 27414. Food Chemistry, 2018, 261: 329-336
5. Wen-Can Huang#, Wei Wang#, Changhu Xue, Xiangzhao Mao*. Effective enzyme immobilization onto a magnetic chitin nanofiber composite.ACS Sustainable Chemistry & Engineering, 2018, 6: 8118-8124
6. Wen-Can Huang #, Dandan Zhao#, Na Guo, Changhu Xue, Xiangzhao Mao*. Green and facile production of chitin from crustacean shells using a natural deep eutectic solvent. Journal of Agricultural and Food Chemistry, 2018, 66, 11897-11901
7. Qidong Wang, Jianan Sun, Zhen Liu, Wen-Can Huang, Changhu Xue, Xiangzhao Mao*. Co-immobilization of β-agarase and α-neoagarobiose hydrolase for enhancing the production of 3,6-anhydro-L-galactose. Journal of Agricultural and Food Chemistry, 2018, 66: 7087-7095
8. Ping Lu, Xinwei Gao, Hao Dong, Zhen Liu, Francesco Secundo, Changhu Xue, Xiangzhao Mao*. Identification of a novel esterase from marine environmental genomic DNA libraries and its application in production of free all-trans-astaxanthin. Journal of Agricultural and Food Chemistry, 2018, 66:2812-2821
9. Xiaoqing Yang, Zhen Liu, Chengcheng Jiang, Jianan Sun, Changhu Xue, Xiangzhao Mao*. A novel agaro-oligosaccharide-lytic β-galactosidase from Agarivorans gilvus WH0801. Applied Microbiology and Biotechnology, 2018, 102(12): 5165-5172
10. Wen-Can Huang, Hui Liu, Weiwei Sun, Changhu Xue, Xiangzhao Mao*. Effective astaxanthin extraction from wet Haematococcus pluvialis using switchable hydrophilicity solvents.ACS Sustainable Chemistry & Engineering, 2018, 6 (2): 1560-1563
11. Yating Zhang, Zhen Liu, Jianan Sun, Changhu Xue, Xiangzhao Mao*. Biotechnological production of zeaxanthin by microorganisms. Trends in Food Science & Technology, 2018, 71: 225-234
12. Xiangzhao Mao*, Zhen Liu, Jianan Sun, Sang Yup Lee*. Metabolic engineering for the microbial production of marine bioactive compounds. Biotechnology Advances, 2017, 35: 1004-1021
13. Yunxiao Liang, Xiaoqing Ma, Lujia Zhang, Fuli Li, Zhen Liu, Xiangzhao Mao*. Biochemical characterization and substrate degradation mode of a novel exo-type β-agarase from Agarivorans gilvus WH0801.Journal of Agricultural and Food Chemistry, 2017, 65 (36): 7982-7988
14. Hao Dong, Francesco Secundo, Changhu Xue, Xiangzhao Mao*. Whole-cell biocatalytic synthesis of cinnamyl acetate with a novel esterase from the DNA library of acinetobacter haemolyticus. Journal of Agricultural and Food Chemistry, 2017: 65 (10), 2120-2128
15. Xiangzhao Mao#,*, Na Guo#, Jianan Sun, Changhu Xue. Comprehensive utilization of shrimp waste based on biotechnological methods: A Review. Journal of Cleaner Production, 2017, 143: 814-823.
16. Jianan Sun, Xiangzhao Mao*. An environmental friendly process for antarctic krill (euphausia superba) utilization using fermentationtechnology. Journal of Cleaner Production, 2016, 127, 618-623.
